Technology Platform Nutraceutical Development BM-A1 Clinical Trial Therapeutic Development Publications

Scientific Publications Lorena Arranz, Nuria M. De Castro, Isabel Baeza, Ianire Mate,Maria Paz Viveros, and Monica De la Fuente-Environmental Enrichment Improves Age-Related Immune System Impairment: Long-Term Exposure Since Adulthood Increases Life Span in Mice.Rejuvenation Research. August 2010, 13(4): 415-428. DOI: 10.1089/rej.2009.0989.PDF Document Paola Sebastiani, Nadia Solovieff, Annibale Puca, Stephen W. Hartley, Efthymia Melista, Stacy Andersen, Daniel A. Dworkis, Jemma B. Wilk, Richard H. Myers, Martin H. Steinberg, Monty Montano, Clinton T. Baldwin, Thomas T. Perls-Genetic Signatures of Exceptional Longevity in Humans. July 1 2010; Science DOI: 10.1126/science.11905 PDF Document Richard A. Stein, M.D., Ph.D. Next Generation Sequencing Moves to Next-Next Level-As Technology Proves Its Mettle and Advances Expand Usage, Applications Are Proliferating. Genetic Engineering and Biotechnology News. Jun 15 2010; 30(12). PDF Document Young-Beob Yu, Laura Dosanjh, Lixing Lao, Ming Tan, Bum Sang Shim, Yuan Luo (2010) Cinnamomum cassia Bark in Two Herbal Formulas Increases Life Span in Caenorhabditis elegans via Insulin Signaling and Stress Response Pathways.PLoS ONE (Public Library of Science). 2010 Feb 22;5(2):e9339.PDF Document Vadim Aksenov, Jiangang Long, Sonali Lokuge, Jane A Foster, Jiankang Liu and C David Rollo-Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Experimental Biology and Medicine. 2010 Jan;235(1):66-76. PDF Document Jiangang Long, Hongxiang Gao, Lijuan Sun, Jiankang Liu, and Xi Zhao-Wilson-Grape Extract Protects Mitochondria from Oxidative Damage and Improves Locomotor Dysfunction and Extends Lifespan in a Drosophila Parkinson's Disease Model. October 2009, 12(5): 321-331. doi:10.1089/rej.2009.0877. PDF Document Joseph Dhahbi, Xichen Li, Tim Tran, Michal M. Masternak, Andrzej Bartke (2007) Circulating blood leukocyte gene expression profiles: Effects of the Ames dwarf mutation on pathways related to immunity and inflammation. Experimental Gerontology. 42 : 772-788. PDF Document Dhahbi J.M. ,Tsuchiya T., Hyon-Jeen K., Mote P.L, & Spindler S.R. (2006) Gene Expression and Physiologic Responses of the heart to the Initiation and Withdrawal of Caloric Restriction. Journal of Gerontology. 61: 218-231. PDF Document Dhahbi J.M. , Mote P.L, Fahy G.M.& Spindler S.R. (2005) Identification of Potential Restriction Mimetics by Microarray Profiling. Physiol Genomics. 23:343-350. PDF Document Kaput J, Ordovas, etal. The case for strategic international alliances to harness nutritional genomics for public and personal health. British Journal of Nutrition (2005), 94, 623–632. PDF Document Dhahbi J.M. & Spindler S.R. (2004) Aging of the Liver, In: Biology of Aging and its Modulation: Aging of the Organs and Systems, Vol. 3, Aspinall R. (Ed.), Kluwer Academic Publishers, Dordecht, The Netherlands, pp. 271-291. PDF format Dhahbi J.M., Mote P.L, Kim H.J. & Spindler S.R. (2004) Temporal Linkage Between the Phenotypic and Genomic Responses to Caloric Restriction. Proc. Natl. Acad. Sci. U.S.A. Apr 13;101(15):5524-9. Epub 2004 Mar 25. PDF format Tsuchiya T., Dhahbi J.M., Cui X., Mote P.L, Bartke A. & Spindler S.R. (2004) Additive Regulation of Hepatic Gene Expression by Dwarfism and Caloric Restriction. Physiol. Genomics, Mar 2004; 10.1152/physiolgenomics.00039.2004. PDF format Spindler S.R. (2003) Caloric Restriction, Longevity and the Search for Authentic Anti-Aging Drugs, In: Anti-Aging Therapy for Plastic Surgery, Kinney B. & Carraway J. (Eds.), Quality Medical Publishing, Inc., St. Louis. In Press. PDF format Spindler S.R., Dhahbi J.M., Mote P.L., Kim H.J. & Tsuchiya T. (2003) Rapid Identification of Candidate CR Mimetics Using Microarrays. Presented at The International Association of Biomedical Gerontology, 10th Congress, Strategies for Engineered Negligible Senescence: Reasons Why Genuine Control of Aging may be Foreseeable, Queens’ College, Cambridge, England, 19-23 September 2003. PDF format Spindler S.R., Dhahbi J.M. & Mote, P.L. (2003) Protein Turnover, Energy Metabolism, Aging, and Caloric Restriction, In: Energy Metabolism and Lifespan Determination: Advances in Cell Aging and Gerontology, Vol. 14, Mattson M.P. (Ed.), Elsevier, Amsterdam, The Netherlands, pp. 69-86. PDF format Cao S.X., Dhahbi J.M., Mote P.L. & Spindler, S.R. (2001) Genomic Profiling of Short- and Long-Term Calorie Restriction in the Liver of Aging Mice. Proc. Natl. Acad. Sci. U.S.A. 98:10630-10635. PDF format Other BioMarker publications, provided upon request Here