Technology Platform Nutraceutical Development BM-A1 Clinical Trial Genetic Information Assessment Therapeutic Development Publications

Scientific Publications Joseph Dhahbi, Xichen Li, Tim Tran, Michal M. Masternak, Andrzej Bartke (2007) Circulating blood leukocyte gene expression profiles: Effects of the Ames dwarf mutation on pathways related to immunity and inflammation. Experimental Gerontology. 42 : 772-788. PDF Document Dhahbi J.M. ,Tsuchiya T., Hyon-Jeen K., Mote P.L, & Spindler S.R. (2006) Gene Expression and Physiologic Responses of the heart to the Initiation and Withdrawal of Caloric Restriction. Journal of Gerontology. 61: 218-231. PDF Document Dhahbi J.M. , Mote P.L, Fahy G.M.& Spindler S.R. (2005) Identification of Potential Restriction Mimetics by Microarray Profiling. Physiol Genomics. 23:343-350. PDF Document Dhahbi J.M. & Spindler S.R. (2004) Aging of the Liver, In: Biology of Aging and its Modulation: Aging of the Organs and Systems, Vol. 3, Aspinall R. (Ed.), Kluwer Academic Publishers, Dordecht, The Netherlands, pp. 271-291. PDF format Dhahbi J.M., Mote P.L, Kim H.J. & Spindler S.R. (2004) Temporal Linkage Between the Phenotypic and Genomic Responses to Caloric Restriction. Proc. Natl. Acad. Sci. U.S.A. Apr 13;101(15):5524-9. Epub 2004 Mar 25. PDF format Tsuchiya T., Dhahbi J.M., Cui X., Mote P.L, Bartke A. & Spindler S.R. (2004) Additive Regulation of Hepatic Gene Expression by Dwarfism and Caloric Restriction. Physiol. Genomics, Mar 2004; 10.1152/physiolgenomics.00039.2004. PDF format Spindler S.R. (2003) Caloric Restriction, Longevity and the Search for Authentic Anti-Aging Drugs, In: Anti-Aging Therapy for Plastic Surgery, Kinney B. & Carraway J. (Eds.), Quality Medical Publishing, Inc., St. Louis. In Press. PDF format Spindler S.R., Dhahbi J.M., Mote P.L., Kim H.J. & Tsuchiya T. (2003) Rapid Identification of Candidate CR Mimetics Using Microarrays. Presented at The International Association of Biomedical Gerontology, 10th Congress, Strategies for Engineered Negligible Senescence: Reasons Why Genuine Control of Aging may be Foreseeable, Queens’ College, Cambridge, England, 19-23 September 2003. PDF format Spindler S.R., Dhahbi J.M. & Mote, P.L. (2003) Protein Turnover, Energy Metabolism, Aging, and Caloric Restriction, In: Energy Metabolism and Lifespan Determination: Advances in Cell Aging and Gerontology, Vol. 14, Mattson M.P. (Ed.), Elsevier, Amsterdam, The Netherlands, pp. 69-86. PDF format Cao S.X., Dhahbi J.M., Mote P.L. & Spindler, S.R. (2001) Genomic Profiling of Short- and Long-Term Calorie Restriction in the Liver of Aging Mice. Proc. Natl. Acad. Sci. U.S.A. 98:10630-10635. PDF format Other BioMarker publications, provided upon request Here