Nutraceuticals: BM-A1/BM-A2/BM-A3 BM-A1 Clinical Trial

Evaluation of BMA-2 as a Calorie Restriction Mimetic BioMarker is studying the effects of BM-A2 on gene expression in mice. Mice fed BM-A2 show similar effects when compared to mice on calorie restricted diets. Results show that there are significant relationships in the types of genes that are affected by BM-A2 compared to mice on a calorie restricted diet. Many genes that control response to DNA damage and repair as well as genes involved in the immune response behave in a similar fashion when the differences in gene expression among these groups are compared. Recently, a randomized controlled clinical study of the effects of calorie restriction in humans found that in addition to significant effects on metabolism, DNA damage was significantly reduced from baseline in those individuals undergoing calorie restriction1. BM-A2 may activate some of the same genes that are positively affected by caloric restriction by modulating DNA damage and repair and providing cells with an enhanced capability for dealing with stress. 1Heilbronn LK, de Jonge L, Frisard MI, DeLany JP, Larson-Meyer DE, Rood J, Nguyen T, Martin CK, Volaufova J, Most MM, Greenway FL, Smith SR, Deutsch WA, Williamson DA, Ravussin E; Pennington CALERIE Team. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA. 2006 Apr 5;295(13):1539-48.